I'm on my way to PyCon soon. It's far too late for me to encourage you to attend. Shame on me for that.
I'll be giving a talk WSGI: An Introduction. I can't figure out how to link to talks on the site, but if you are really curious you can see my slides as they progress. I plan to talk about architecture a lot: about how to use WSGI-based tools to construct web sites, not just individual web applications. And maybe I should use some of the planned design of the OpenPlans architecture as an example.
Also, I'll have a chance to talk some about when or if WSGI middleware is harmful, and WSGI Framework Components, and whatever other thoughts I can fit in.
See ya there...