"twisted Fine ideas, very promising, but needs a complete new way of development. I read the docco several hours. It is just too different from everything else, so it is ruled out. You'll never set up some hello world examples after 2 hours like with JSP."
The web is only a small part of twisted. Or did you mean Nevow? I think you could pick of the basics of Nevow very quickly without knowing much about twisted, though you do eventually need to pick up some twisted basics like deferreds, adapters, realms, etc. to be fully proficient with it. The main problem with Nevow as an application framework is the lack of integration with an ORM and the immaturity of some parts (e.g. formless needs a lot of work to be useful for more than simple forms.)