The thing I love most about Python is that many of its APIs are intuitive and obvious. Compare, e.g. reading a line from a text file in Python and in Java. Sometimes when I use a new standard library module I don't even have to go read its documentation: a brief glance with pydoc suffices to show the method or class names, and the rest is obvious.
Distutils, sadly, is an exception. Despite reading the documentation and creating three setup.py files, I do not feel comfortable with it. If I were stranded on a desert island with no Internet access and no documentation, I could not write a setup.py file.