Ian Bicking: the old part of his blog

Comment

ctypes is pretty great, but caveat emptor..
(a) there's no automatic way to convert a C header to ctypes code
(b) some C-isms are terribly difficult to express in ctypes code
(c) debugging ctypes code is HARD

pyrex still has (a), partially solves (b), and almost entirely solves (c).
Comment on Nummy ctypes
by Bob Ippolito