Corey: psyco (http://psyco.sf.net) can give some wonderful speedups with just two line of codes inserted at the begining of your module. It only works on i386 arch for now though.
Now to answer your question more precisely, there is no such document, though http://www.python.org/doc/essays/list2str.html is one of the references on the topic. http://trific.ath.cx/resources/python/optimization/ is also a nice one (and they both come on the first page when googling for "python optimization"). The key thing is that you should never ever optimize blindly. Learn how to use the profiler module to find the bottleneck of your application and this is the only place where you should ever optimize. Make your code work in the first place. Make it clean. Make it readable. Then and not before, find the bottleneck (if any) .